Reactine duo nebenwirkungen

REACTINE™

Pfizer Consumer

Cetirizine HCl

Histamine H1-Receptor Antagonist

Action And Clinical Pharmacology: Cetirizine, a human metabolite of hydroxyzine, is a histamine H1 receptor antagonist anti-allergic compound; its principal effects are mediated via selective inhibition of peripheral H1 receptors.

Taking more than the usual dose is unlikely to harm you or your child. However, a percentage of people do find it to be sedating so if it does make you drowsy it is best to take it in the evening.

You should start to feel better within an hour. 

Reactine, Tabletten depends on why you're taking.You may only need to take it for a short time or as a one-off dose.

Usually, Reactine, Tabletten start to work within 30 minutes after being taken and tend to be most effective within 1-2 hours after being taken.

Reactine, Tabletten is also used to treat itching and redness caused by hives.

Reactine, Tabletten is unlikely to do you any harm if you take it for a long time.

Its duration of action is at least 24 hours.

Tell your doctor if you have or have ever had kidney or liver disease. For twice daily dosing, one 5 mg (regular strength) film-coated tablet in the morning and one 5 mg filmcoated tablet in the evening.

It is best to take Reactine, Tabletten only for as long as you need to. Consult a doctor if unsure about dosage.

Note: 20 mg film-coated tablets are only available under prescription; please consult your physician

Capsules (liquid gels)

• Adults and children 12 years of age and over: One 10 mg capsule, once daily.

Syrup (taken with or without food)

• Children 2-6 years of age: 5 mL of syrup given once daily.

  Cetirizine is distinguished from other histamine H1 receptor antagonists by the presence of a carboxylic acid function. In clinical studies, however, dry mouth was found to be more frequent with cetirizine than with a placebo. Studies with radiolabeled cetirizine administration in the rat have demonstrated insignificant penetration into the brain.

  There was no evidence of jaundice or hepatitis, and the clinical significance is presently unknown. Plasma levels are unaffected by hemodialysis.

  Management: Symptomatic and supportive treatment. Dose adjustment is required for patients with moderate to severe renal impairment and in patients on hemodialysis . Gastric lavage may be done shortly following ingestion.

  Storage Condition

  Store between 20-25°C.

  

  The time of administration, with or without food, may be varied to suit individual patient needs.

  In patients with moderate hepatic and/or renal impairment or adults 65 years and over, a starting dose of 5 mg/day is recommended.

  REACTINE should not be administered to children under 2 years of age, unless advised by a physician.

  Clinical studies to date support treatment for up to 6 months thus medical recommendation is advised for long-term use.

  Specific dosing directions for various dosage forms of REACTINE are provided below:

  Tablets (taken with or without food)

  • Children 6-12 years of age: One 10 mg (extra strength) tablet (film-coated or orally disintegrating tablet), once daily.

    Concurrent use of cetirizine with alcohol or other CNS depressants should be avoided because additional reduction in alertness and CNS performance may occur.

    Interaction

    No clinically significant drug interactions have been found with theophylline, azithromycin, pseudoephedrine, ketoconazole or erythromycin and with some other drugs.

    Food Interaction

    • Avoid alcohol.
    • Take with or without food.

      Bioavailability was found to be similar between the tablet and syrup dosage forms. The plasma elimination half-life is approximately 8 to 9 hours and does not change with multiple dosing. The incidence of discontinuation due to adverse reactions in patients receiving cetirizine was not significantly different from placebo (1.0% vs 0.6%, respectively, in placebo-controlled trials).

      Use in breastfeeding/nursing

      Reactine, Tabletten has been reported to be excreted in human breast milk. The absorption is unaffected by food.

    [Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.

    Use in combination may result in additive central nervous system depression and

    Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

    Drug Interaction

    Moderate: diphenhydramine, diphenhydramineUnknown: aspirin, aspirin, omega-3 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acids, fluticasone nasal, fluticasone nasal, albuterol, albuterol, montelukast, montelukast, acetaminophen, acetaminophen, cyanocobalamin, cyanocobalamin, ascorbic acid, ascorbic acid, cholecalciferol, cholecalciferol

    Disease Interaction

    Moderate: alcohol, renal/liver disease

    Volume of Distribution

    Apparent volume of distribution: 0.44 +/- 0.19 L/kg .

    Treatment should be symptomatic and supportive taking into account any concomitantly ingested medications. In most people it is non-sedating, so they take it in the morning. The use of cetirizine in nursing mothers is not recommended .

    Precaution

    Caution should be exercised when driving a car or operating a heavy machinery.